If you experience higher than normal system pressure; this may have been caused by one of the reasons below.
| Causes | Solutions |
| Flow rate set too high | - Reduce flow rate setting. Use Smart FlowPilot (if applicable) |
| Blocked column | - Backflush column (if permitted) or replace column. |
| Incompatible mobile phase (precipitated buffer or immiscible) | - Use correct mobile phase; wash column and re-equilibrate. |
| Improper column | - Use correct column with correct dimensions and particle geometry. |
| Injector blockage | - Clear blockage (review needle, loop, valve assembly and HPV outlet). |
| Guard column / cartridge blockage | - Replace or remove guard column. |
| Column in-line filter blockage | - Replace or remove in-line filter. |
| Column temperature too low | - Set adequate column temperature. |
| Sensor malfunction | - Repair or replace pressure sensor. |
| Pump in-line filter blockage | - Replace in-line filter. |
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