SFC Separation of racemic Verapamil

+/- Racemic Verapamil is prescribed as treatment for Angina. Although one enantiomer is more potent.

System: Nexera UC - SFC System

Mobile phase: 20% 15 mM Ammonium acetate in IPA : 80% supercritical Carbon Dioxide

BPR: 100 bar

Oven: 30 degC

PDA: @278 nm

Column: Lux Cell-4, 250 x 4.6 mm

Flow: 4 mL/min