Sequence Analysis of Antisense Nucleic Acid (oligonucleotide) using MALDI-8030

Mass spectrometry (MS) has now become an established analytical tool for analyzing biopolymers, such as nucleic acids, proteins, and glycans, thanks to the development of various soft ionization methods and instrument performance improvements.

Although tandem mass spectrometry (MS/MS) is generally used to sequence nucleic acids, collision-induced dissociation (CID), the technique typically used for conventional ion cleavage, has been
problematic because of the difficulty in producing fragments that suggest particularly internal sequences.

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Sequence Analysis of Antisense Nucleic Acid using MALDI-8030